248 HLA-B58 Does not Increase Allopurinol Hypersensitivity among Patients with Hematologic Malignancy
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248 HLA-B58 Does not Increase Allopurinol Hypersensitivity among Patients with Hematologic Malignancy
247 Health-Related Quality of Life and Prognostic Value of Acoustic Rhinometry in Patients With Perennial Allergic Rhinitis Treated with Fix Combination of Montelukast Plus Desloratadine Cemal Cingi, MD, ORL & HNS, Fatih Oghan, MD, ORL & HNS, DPU, Gorkem Eskiizmir, MD, ORL & HNS, Aytekin Yaz, MD, ORL & HNS, Ahmet Ural, ORL & HNS, and Nagehan Erdogmus, ORL & HNS. Osmangazi University, Faculty of...
متن کاملAllopurinol Hypersensitivity in Hematologic Malignancy
Allopurinol, a widely used urate-lowering agent, is a leading cause of severe cutaneous adverse reactions (SCARs), especially in patients with HLA-B*58:01. Despite its routine use for the prevention of tumor lysisrelated hyperuricemia prior to chemotherapy, the risk of allopurinol-induced hypersensitivity has not been investigated in patients with hematologic malignancies. This retrospective co...
متن کاملHLA-B58 can help the clinical decision on starting allopurinol in patients with chronic renal insufficiency.
BACKGROUND Although allopurinol is a very effective urate-lowering drug for complicated hyperuricemia, in some patients, it can induce severe cutaneous adverse reactions (SCARs). Recent investigations suggest that HLA-B*5801 is a very strong marker for allopurinol-induced SCARs, especially in the population with a high frequency of HLA-B*5801. Korea is one of the countries with a high frequency...
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PURPOSE Bevacizumab (Bev) is associated with improved progression-free survival in advanced epithelial ovarian cancer. The use of Bev in patients with gynecologic malignancy is increasing; however, little is known about cumulative toxicity and response in patients retreated with Bev. Our goal was to determine cumulative side effects and response in patients retreated with Bev. PATIENTS AND ME...
متن کاملCorrelation of Tissue Distribution of HLA-G and HLA-E and Degree of Tumor Malignancy in Patients with Breast Cancer
Background and Aims: Human leukocyte antigen (HLA) molecules play a substantial role in T Lymphocyte-mediated adaptive immune response. Down-regulation of HLA expression may help the tumor to escape from immune surveillance. This study aimed to evaluate the correlation between HLA-G and HLA-E tissue distribution and the degree of tumor malignancy in human breast tumors. Materials and Methods:...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2012
ISSN: 1939-4551
DOI: 10.1097/01.wox.0000412005.38490.43